Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Use Caution/Monitor. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics. lorazepam and opium tincture both increase sedation. Comment: Teduglutide may increase absorption of concomitant PO medications; caution with with drugs requiring titration or those with a narrow therapeutic index; dose adjustment may be necessary. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada). Benzodiazepines, such as lorazepam and midazolam, are frequently administered to surgical intensive care unit (ICU) patients for postoperative sedation. Use Caution/Monitor. Use Caution/Monitor. Consult your doctor for more details. lorazepam, metoclopramide intranasal. Objectives: FOIA Cessation of benzodiazepines or other CNS depressants is preferred in most cases. Use Caution/Monitor. Monitor Closely (1)suvorexant and lorazepam both increase sedation. Effect of interaction is not clear, use caution. <> Monitor Closely (1)propofol and lorazepam both increase sedation. 0000010283 00000 n ofloxacin increases levels of lorazepam by decreasing metabolism. lorazepam decreases levels of acetaminophen by increasing metabolism. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Use Caution/Monitor. Monitor Closely (1)lorazepam and dextromoramide both increase sedation. Desirable interaction enhanced memory improvement (based on preliminary trial). ID - 787140 . Complications of sedation with midazolam in the intensive care unit and a comparison with other sedative regimens. Before Monitor for drug toxiticities when initiating or discontinuing methylphenidate. azelastine and lorazepam both increase sedation. levofloxacin increases levels of lorazepam by decreasing metabolism. Use Caution/Monitor. Use Caution/Monitor. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.This drug passes into breast milk. Monitor Closely (1)lorazepam and daridorexant both increase sedation. If used, choose an agent with a shorter half-life. Use Caution/Monitor. DP - Unbound Medicine lorazepam and mirtazapine both increase sedation. Modify Therapy/Monitor Closely. Y1 - 2016/12/19/ lorazepam and nortriptyline both increase sedation. Monitor Closely (1)lorazepam and doxylamine both increase sedation. Monitor Closely (1)carbinoxamine and lorazepam both increase sedation. Your message has been successfully sent to your colleague. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Use Caution/Monitor. Effect of interaction is not clear, use caution. NOTES: Lifestyle changes such as starting a stress reduction program may increase the effectiveness of this medication. lorazepam and clozapine both increase sedation. Monitor Closely (1)lorazepam increases and armodafinil decreases sedation. WebPharmacist initiated IV to PO conversion program of antimicrobials. Oral dose equivalences of benzodiazepines. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Monitor Closely (1)lorazepam and desipramine both increase sedation. Effect of interaction is not clear, use caution. Lorazepam may harm an unborn baby. lorazepam and chloral hydrate both increase sedation. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. 4 0 obj Risk for sedation increased if flibanserin is coadministration with other CNS depressants. Monitor Closely (1)lorazepam and cyclobenzaprine both increase sedation. Modify Therapy/Monitor Closely. Use Caution/Monitor. 0000004027 00000 n Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Either increases toxicity of the other by pharmacodynamic synergism. Monitor Closely (1)teduglutide increases levels of lorazepam by Other (see comment). depression, hypotension. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. diphenhydramine and lorazepam both increase sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. xb```i\ cc`a4xq`1 cfLk2^eMab\`Y9N"Nykf46tH h)i:b4Y,Q!a6[CNbaP+" Effect of interaction is not clear, use caution. Minor (1)levofloxacin increases levels of lorazepam by decreasing metabolism. Monitor Closely (2)lorazepam, loxapine. WebDose-dependent conversions: The conversion ratio of certain opioids can be dependent on the dose of the original opioid. Monitor Closely (1)lorazepam and papaverine both increase sedation. Use Caution/Monitor. Monitor Closely (1)diphenhydramine and lorazepam both increase sedation. . Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. This information is not individual medical advice and does not substitute for the advice of your health care professional. Monitor Closely (1)lorazepam and motherwort both increase sedation. Use Caution/Monitor. Effect of interaction is not clear, use caution. <> Minor/Significance Unknown. Monitor Closely (1)hydroxyzine and lorazepam both increase sedation. Applies only to oral form of both agents. Minor/Significance Unknown. Use Caution/Monitor. Most Modify Therapy/Monitor Closely. chlorpheniramine and lorazepam both increase sedation. lorazepam increases and epinephrine racemic decreases sedation. -yuRm]M Minor/Significance Unknown. lorazepam increases and armodafinil decreases sedation. Minor (1)lorazepam decreases effects of vecuronium by pharmacodynamic antagonism. HOW TO USE: See also Warning section.Read the Medication Guide provided by your pharmacist before you start taking lorazepam and each time you get a refill. If necessary, adjust dose of alprazolam as needed, Monitor levels of digoxin, and reduce dose as needed, Adjust dose of diazepam as needed, or change to a benzodiazepine eliminated by glucuronidation, Reduce starting dose of alprazolam by 50%; adjust dose further as needed, Alprazolam, diazepam Fosamprenavir (Lexiva), Chlordiazepoxide, clonazepam ketoconazole, Diazepam, lorazepam olanzapine (Zyprexa), Increased risk of cardiorespiratory depression, Avoid use of parenteral benzodiazepines and IM olanzapine, Diazepam phenyton (Dilantin), fosphenytoin (Cerebyx), Monitor phenytoin levels, and adjust dose as needed, Reduce lorazepam starting dose by 50%; adjust dose further as needed, Alprazolam, clonazepam, diazepam ritonavir (Norvir), Alprazolam, diazepam saquinavir (Invirase), Increased sedative/CNS depressant effects, Monitor for sedative effects, and adjust dose of one or both as needed, Monitor for increased sedative/CNS depressant effects, Start tapentadol at 1/3 to 1/2 the usual starting dose. endobj Effect of interaction is not clear, use caution. Minor/Significance Unknown. BT - Johns Hopkins Psychiatry Guide Unauthorized use of these marks is strictly prohibited. Use Caution/Monitor. Use Caution/Monitor. Therapeutic implications. As needed benzodiazepine doses were administered in 38% of encounters post conversion, but escalation of a scheduled enteral benzodiazepine regimen was only required in 2.8% of encounters. Either increases toxicity of the other by pharmacodynamic synergism. WebNAME Generic (Brand) Approx. Use Caution/Monitor. [7Yy ]6IF  Use Caution/Monitor. An official website of the United States government. lorazepam and olopatadine intranasal both increase sedation. Individual plans may vary Use Caution/Monitor. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Effect of interaction is not clear, use caution. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects. Effect of interaction is not clear, use caution. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Use Caution/Monitor. The authors have disclosed that they do not have any potential conflicts of interest. Consider decreasing the dose of these drugs when given coadministered with methylphenidate. lorazepam and maprotiline both increase sedation. Use Caution/Monitor. Monitor Closely (1)lorazepam and trazodone both increase sedation. Effect of interaction is not clear, use caution. Monitor Closely (1)gabapentin enacarbil, lorazepam. Profound sedation, respiratory depression, coma, and death may result if coadministered. Use Caution/Monitor. Minor/Significance Unknown. Adv Emerg Nurs J. clonidine, lorazepam. Monitor Closely (1)lorazepam and pentazocine both increase sedation. lorazepam increases and dexmethylphenidate decreases sedation. and formulary information changes. Minor/Significance Unknown. lorazepam and daridorexant both increase sedation. F"5!oofXcxe2"&GQ.gXc'Oi\ZtR{T=26og(> O+GQ>CqL\VD0sRlKt>BRBkjsDMl:l|n]j8)wYna%Hw m8Z;[Ogk{bno_7.Gcv,nb-9r! lorazepam increases and phendimetrazine decreases sedation. Bellantuono C, Tofani S, Di Sciascio G, et al. Use Caution/Monitor. lorazepam and trifluoperazine both increase sedation. Anxiolytics: past, present, and future agents. x}n y)Zn91Iv l38Y8bIkYbX$=x:9\>?}st_~xOo^\~dt&&=\~o~g/}~y%;]V|s{h+j/~\f'iqriwZgI~IOk[b,n6'K+%Y{Y?k{]U4{H}mWRa |3}ktz_>iCy>VbZ{SZ(_!> _~{pz.5'Kxo'wW0P*okGa? Talk to your doctor if you are using marijuana (cannabis).Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Older adults may be more sensitive to the side effects of this drug, especially loss of coordination and drowsiness. informational and educational purposes only. Information last revised December 2022. Use Caution/Monitor. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. perampanel and lorazepam both increase sedation. Use Caution/Monitor. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Monitor Closely (1)lorazepam and midazolam both increase sedation. As needed benzodiazepine doses were administered in 38% of encounters post conversion, but escalation of a scheduled enteral benzodiazepine regimen was only required in 2.8% of encounters. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. Intravenous to Oral Conversion for Antimicrobials 1-20-6-1-010 Author(s): Antimicrobial Stewardship Program Coordinator Page 6 of 6 Issuing Authority: Vice President Medicine and Clinical Programs; Regional Director, Pharmacy Services Modify Therapy/Monitor Closely. Biotin supplementation may be necessary. sharing sensitive information, make sure youre on a federal WebBackground. Theoretical interaction; some species of sage may cause convulsions. Mechanism: unknown. Minor/Significance Unknown. Either increases toxicity of the other by pharmacodynamic synergism. Data is temporarily unavailable. T1 - Benzodiazepines Many people using this medication do not have serious side effects.Tell your doctor right away if you have any unlikely but serious side effects, including: mental/mood changes (such as hallucinations, depression, thoughts of suicide), trouble speaking, vision changes, unusual weakness, trouble walking, memory problems, signs of infection (such as sore throat that doesn't go away, fever).Get medical help right away if you have any rare but very serious side effects, including: yellowing eyes or skin, seizures, slow/shallow breathing.This medication can rarely have the opposite of its usual calming effect. lorazepam and droperidol both increase sedation. Minor/Significance Unknown. -L Use Caution/Monitor. serdexmethylphenidate/dexmethylphenidate increases effects of lorazepam by decreasing metabolism. Minor/Significance Unknown. Both drugs can cause metabolic acidosis. Use Caution/Monitor. Monitor Closely (1)lorazepam increases and formoterol decreases sedation. Use Caution/Monitor. The above information is provided for general Use Caution/Monitor. Use Caution/Monitor. lorazepam increases and terbutaline decreases sedation. Monitor Closely (1)lorazepam and methocarbamol both increase sedation. Use Caution/Monitor. Minor/Significance Unknown. The median Withdrawal Assessment ToolVersion 1 scores pre conversion and post conversion were not significantly different (1 [interquartile range, 0.752] and 1 [interquartile range, 0.252], respectively, p = 0.1). Minor/Significance Unknown. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Use Caution/Monitor. lorazepam and oxycodone both increase sedation. WARNING: Lorazepam has a risk for abuse and addiction, which can lead to overdose and death. Cannabidiol may potentially inhibit UGT2B7 activity. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. Use Caution/Monitor. Lugo RA, Chester EA, Cash J, Grant MJ, Vernon DD. Effect of interaction is not clear, use caution. Studies have shown that the combination of benzodiazepines and buprenorphine altered the usual ceiling effect on buprenorphine-induced respiratory depression, making the respiratory effects of buprenorphine appear similar to those of full opioid agonists. lorazepam increases and benzphetamine decreases sedation. Use Caution/Monitor. Monitor Closely (1)chlorpheniramine and lorazepam both increase sedation. Either increases effects of the other by pharmacodynamic synergism. These findings suggest that standardized benzodiazepine conversions successfully achieved consistent Withdrawal Assessment ToolVersion 1 scores compared with preconversion values. 3 0 obj Applies only to oral form of both agents. x]r}g*~qXE-GmqyHJbBr^|c],^ @r\4Plxy+XNr^X/ Use Caution/Monitor. 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